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Visualizing Proteins in Human Cells at Near‐Physiological Concentrations with Sensitive 19 F NMR Chemical Tags

27 Mar 2023

Abstract excerpt

Abstract In‐cell NMR spectroscopy is an effective tool for observing proteins at atomic resolution in their native cellular environment. However, its utility is limited by its low sensitivity and the extensive line broadening caused by nonspecific interactions in the cells, which is even more pronounced in human cells due to the difficulty of overexpressing or delivering high concentrations of isotopically...

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PMID: 36973575
DOI: 10.1002/anie.202300318

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