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Temperature-induced reactivation of Marek's disease virus-transformed T cells ex vivo

8 Mar 2023

Abstract excerpt

Marek's disease virus (MDV) establishes latency in chicken T lymphocytes that can lead to T cell transformation and cancer. Transformed Marek's disease chicken cell lines (MDCCs) can be expanded ex vivo and provide a valuable model to study latency, transformation, and reactivation. Here, we developed MDCCs from chickens infected with MDV that fluoresce during lytic replication and reactivation. Sodium butyrate...

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Identifiers

PMID: 36968465
DOI: 10.3389/fvets.2023.1145757

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