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In vitro model for lytic replication, latency, and transformation of an oncogenic alphaherpesvirus

26 May 2015

Abstract excerpt

Marek's disease virus (MDV) is an alphaherpesvirus that causes deadly T-cell lymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation. In vivo, MDV lytically replicates in B cells that transfer the virus to T cells in which the virus establishes latency. MDV also malignantly transforms CD4+ T cells with a T(reg) signature, ultimately resulting in deadly lymphomas. No in...

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PMID: 26039998
DOI: 10.1073/pnas.1424420112

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