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Marek's disease virus reactivation from latency: changes in gene expression at the origin of replication

1 Jun 2003

Abstract excerpt

Marek's disease is a contagious lymphoma of chickens caused by Marek's disease virus (MDV). MDV replicates in chicken lymphocytes and establishes latency within and transforms chicken CD4+ T-cells. Transformed T-cells are seen as skin leukosis or as lymphomas in visceral organs. A major focus of our laboratory is the functional study of genes flanking the origin of replication. This origin (OriLyt) is contained...

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PMID: 12817443
DOI: 10.1093/ps/82.6.893

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