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Article

Cancer in Costello syndrome: a systematic review and meta-analysis.

British journal of cancer - 1 Jun 2023

Astiazaran-Symonds Esteban, Ney Gina M, Higgs Cecilia, Oba Leatrisse, Srivastava Radhika, Livinski Alicia A, Rosenberg Philip S, Stewart Douglas R

Abstract excerpt

BACKGROUND: Costello syndrome (CS) is a cancer-predisposition disorder caused by germline pathogenic variants in HRAS. We conducted a systematic review using case reports and case series to characterise cancer risk in CS. METHODS: We conducted a systematic review to identify CS cases to create a retrospective cohort. We tested genotype-phenotype correlations and calculated cumulative incidence and hazard rates...

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Identifiers

PMID: 36966234
DOI: 10.1038/s41416-023-02229-7
PMCID: PMC10205753

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