Article
Prevalence of bladder cancer in Costello syndrome: New insights to drive clinical decision-making.
Clinical genetics - 1 Apr 2022
Leoni Chiara, Paradiso Filomena Valentina, Foschi Nazario, Tedesco Marta, Pierconti Francesco, Silvaroli Sara, Diego Mario Di, Birritella Lisa, Pantaleoni Francesca, Rendeli Claudia, Onesimo Roberta, Viscogliosi Germana, Bassi Pierfrancesco, Nanni Lorenzo, Genuardi Maurizio, Tartaglia Marco, Zampino Giuseppe
Abstract excerpt
Costello syndrome (CS) is a rare disorder affecting development and growth characterized by cancer predisposition and caused by mutations in HRAS proto-oncogene. Somatic HRAS mutations drive bladder carcinogenesis. The aim of this study was to analyze prevalence and histological characterization of bladder cancer (BC) in a cohort of patients with CS to help clinicians plan effective management strategies. This...
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