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Identification of molecularly unique tumor-associated mesenchymal stromal cells in breast cancer patients

20 Mar 2023

Abstract excerpt

The tumor microenvironment is a complex mixture of cell types that bi-directionally interact and influence tumor initiation, progression, recurrence, and patient survival. Mesenchymal stromal cells (MSCs) of the tumor microenvironment engage in crosstalk with cancer cells to mediate epigenetic control of gene expression. We identified CD90+ MSCs residing in the tumor microenvironment of patients with invasive...

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PMID: 36940196
DOI: 10.1371/journal.pone.0282473

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