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Article

Comparison of genomic profiling of circulating tumor DNA in pancreaticobiliary malignancies in plasma and bile.

Cancer - 1 Jun 2023

Ohyama Hiroshi, Hirotsu Yosuke, Amemiya Kenji, Miura Yoshifumi, Hirose Sumio, Oyama Toshio, Iimuro Yuji, Kojima Yuichiro, Mikata Rintaro, Mochizuki Hitoshi, Kato Naoya, Omata Masao

Abstract excerpt

BACKGROUND: Obtaining sufficient pancreaticobiliary tumor tissue for genomic profiling has limitations. Liquid biopsies using plasma do not provide sufficient sensitivity. Thus, this study aimed to determine the effectiveness of liquid biopsy between bile and plasma for identifying oncogenic and drug-matched mutations. METHODS: This study created a panel of 60 significantly mutated genes specific to...

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PMID: 36932987
DOI: 10.1002/cncr.34717

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