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Fecal microbiota from MRL/lpr mice exacerbates pristane-induced lupus

16 Mar 2023

Abstract excerpt

BACKGROUND: The roles of gut microbiota in the pathogenesis of SLE have been receiving much attention during recent years. However, it remains unknown how fecal microbiota transplantation (FMT) and microbial metabolites affect immune responses and lupus progression. METHODS: We transferred fecal microbiota from MRL/lpr (Lpr) mice and MRL/Mpj (Mpj) mice or PBS to pristane-induced lupus mice and observed disease...

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PMID: 36927795
DOI: 10.1186/s13075-023-03022-w

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