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Article

Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer.

Cancer research communications - 1 Sept 2022

Graf Ryon P, Fisher Virginia, Creeden James, Schrock Alexa B, Ross Jeffrey S, Nimeiri Halla, Oxnard Geoffrey R, Klempner Samuel J

Abstract excerpt

Patients with advanced gastroesophageal cancer (mEG) and tumor mutational burden ≥10 mut/Mb (TMB ≥ 10) have more favorable outcomes on immune checkpoint inhibitor (ICPI) monotherapy compared with chemotherapy in subgroup analyses of randomized controlled trials. We sought to evaluate the robustness of these associations in real-world settings where patients and practices are more diverse. A total of 362 2 L and...

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Source

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Identifiers

PMID: 36922935
DOI: 10.1158/2767-9764.CRC-22-0161
PMCID: PMC10010289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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