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A Systematic Review and Meta-Analysis of the Impact of Tumour Mutation Burden on Survival Outcomes in Solid Tumours

2025-02-05

Abstract excerpt

<h4>Background</h4> Tumour mutation burden (TMB) is an emerging pan-cancer biomarker with potential predictive value for immune checkpoint inhibitor (ICI) therapy outcomes. However, its prognostic significance remains inconsistent due to methodological variability and differing cut-off thresholds. This systematic review and meta-analysis evaluated the impact of TMB on overall survival (OS) and progression-free sur...

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Literature Corpus work
4efe0295-655f-5729-b016-f31224d6a289
DOI
10.1101/2025.02.03.25321619
Open publication

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A Systematic Review and Meta-Analysis of the Impact of Tumour Mutation Burden on Survival Outcomes in Solid TumoursDOI 10.1101/2025.02.03.25321619
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