Article
Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways.
Molecular cancer - 7 Mar 2017
Ibrahim Sherif Abdelaziz, Gadalla Ramy, El-Ghonaimy Eslam A, Samir Omnia, Mohamed Hossam Taha, Hassan Hebatallah, Greve Burkhard, El-Shinawi Mohamed, Mohamed Mona Mostafa, Götte Martin
Abstract excerpt
BACKGROUND: Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular markers of IBC is of major importance. The heparan sulfate proteoglycan Syndecan-1 acts as a coreceptor for growth factors and chemokines, modulating inflammation, tumor progression, and cancer...
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