Article
Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes.
The Journal of allergy and clinical immunology - 1 Jul 2023
Hvidtfeldt Morten, Sverrild Asger, Pulga Alexis, Frøssing Laurits, Silberbrandt Alexander, Hostrup Morten, Thomassen Martin, Sanden Caroline, Clausson Carl Magnus, Siddhuraj Premkumar, Bornesund Daisy, Nieto-Fontarigo Juan Jose, Uller Lena, Erjefält Jonas, Porsbjerg Celeste
Abstract excerpt
BACKGROUND: Airway hyperresponsiveness is a hallmark of asthma across asthma phenotypes. Airway hyperresponsiveness to mannitol specifically relates to mast cell infiltration of the airways, suggesting inhaled corticosteroids to be effective in reducing the response to mannitol, despite low levels of type 2 inflammation. OBJECTIVE: We sought to investigate the relationship between airway hyperresponsiveness and...
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