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Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens

1 Mar 2023

Abstract excerpt

Opioid use disorder (OUD) is a chronic disease characterized by compulsive opioid taking and seeking, affecting millions of people worldwide. The high relapse rate is one of the biggest challenges in treating opioid addiction. However, the cellular and molecular mechanisms underlying relapse to opioid seeking are still unclear. Recent studies have shown that DNA damage and repair processes are implicated in a...

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PMID: 36907467
DOI: 10.1016/j.pbb.2023.173535

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