Article
Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain.
The Journal of biological chemistry - 21 Dec 2012
Fowler Anna-Kate, Hewetson Aveline, Agrawal Rajiv G, Dagda Marisela, Dagda Raul, Moaddel Ruin, Balbo Silvia, Sanghvi Mitesh, Chen Yukun, Hogue Ryan J, Bergeson Susan E, Henderson George I, Kruman Inna I
Abstract excerpt
The brain is one of the major targets of chronic alcohol abuse. Yet the fundamental mechanisms underlying alcohol-mediated brain damage remain unclear. The products of alcohol metabolism cause DNA damage, which in conditions of DNA repair dysfunction leads to genomic instability and neural death. We propose that one-carbon metabolism (OCM) impairment associated with long term chronic ethanol intake is a key...
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