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Article

Application of Nicotinamide to Culture Medium Improves the Efficiency of Genome Editing in Hexaploid Wheat.

International journal of molecular sciences - 23 Feb 2023

Wang Wanxin, Huang Peipei, Dai Wenshuang, Tang Huali, Qiu Yuliang, Chang Yanan, Han Zhiyang, Li Xi, Du Lipu, Ye Xingguo, Zou Cheng, Wang Ke

Abstract excerpt

Histone acetylation is the earliest and most well-characterized of post-translation modifications. It is mediated by histone acetyltransferases (HAT) and histone deacetylases (HDAC). Histone acetylation could change the chromatin structure and status and further regulate gene transcription. In this study, nicotinamide, a histone deacetylase inhibitor (HDACi), was used to enhance the efficiency of gene editing in...

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Identifiers

PMID: 36901844
DOI: 10.3390/ijms24054416
PMCID: PMC10002385

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