Article
No correlation between MTHFR c.677 C > T, MTHFR c.1298 A > C, and ABCB1 c.3435 C > T polymorphisms and methotrexate therapeutic outcome of rheumatoid arthritis in West Algerian population.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Jun 2017
Boughrara Wefa, Benzaoui Ahmed, Aberkane Meriem, Moghtit Fatima Zohra, Dorgham Samia, Lardjam-Hetraf Aicha Sarah, Ouhaibi-Djellouli Hadjer, Teixeira Elisabeth Petit, Boudjema Abdallah
Abstract excerpt
CONTEXT: The c.677 C > T and c.1298 A > C polymorphisms of methylenetatrahydrofolate reductase (MTHFR) gene and c.3435 C > T polymorphism of ATP-Binding cassette B1 (ABCB1) gene are reported as pharmacogenetic markers, influencing the methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA) patients. OBJECTIVES: The aims of this study were to determine the relationship between these polymorphisms and...
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