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Study on molecular mechanisms of CD4 dependency and independency of HIV-1 gp120

1 Jan 2023

Abstract excerpt

Different HIV-1 strains have different antibody neutralization phenotypes (or CD4-dependencies). However, the molecular mechanisms underlying these differences remain to be elucidated. In this study, we constructed gp120 structural models from the CD4-dependent, neutralization-resistant JR-FL strain and the CD4-independent, neutralization-sensitive R2 strain and carried out several conventional molecular dynamics...

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PMID: 36825290
DOI: 10.1039/d3ra00433c

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