Article
Association of low-frequency and rare coding variants with information processing speed.
Translational psychiatry - 4 Dec 2021
Bressler Jan, Davies Gail, Smith Albert V, Saba Yasaman, Bis Joshua C, Jian Xueqiu, Hayward Caroline, Yanek Lisa, Smith Jennifer A, Mirza Saira S, Wang Ruiqi, Adams Hieab H H, Becker Diane, Boerwinkle Eric, Campbell Archie, Cox Simon R, Eiriksdottir Gudny, Fawns-Ritchie Chloe, Gottesman Rebecca F, Grove Megan L, Guo Xiuqing, Hofer Edith, Kardia Sharon L R, Knol Maria J, Koini Marisa, Lopez Oscar L, Marioni Riccardo E, Nyquist Paul, Pattie Alison, Polasek Ozren, Porteous David J, Rudan Igor, Satizabal Claudia L, Schmidt Helena, Schmidt Reinhold, Sidney Stephen, Simino Jeannette, Smith Blair H, Turner Stephen T, van der Lee Sven J, Ware Erin B, Whitmer Rachel A, Yaffe Kristine, Yang Qiong, Zhao Wei, Gudnason Vilmundur, Launer Lenore J, Fitzpatrick Annette L, Psaty Bruce M, Fornage Myriam, Arfan Ikram M, van Duijn Cornelia M, Seshadri Sudha, Mosley Thomas H, Deary Ian J
Abstract excerpt
Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research...
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