Article
The development of familial hypertrophic cardiomyopathy: from mutation to bedside.
European journal of clinical investigation - 1 May 2011
Brouwer Wessel P, van Dijk Sabine J, Stienen Ger J M, van Rossum Albert C, van der Velden Jolanda, Germans Tjeerd
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is a familial disorder characterized by left ventricular hypertrophy in the absence of other cardiac or systemic disease likely to cause this hypertrophy. HCM is considered a disease of the sarcomere as most causal mutations are identified in genes encoding sarcomeric proteins, although several other disorders have also been linked to the HCM phenotype. The clinical course of HCM...
Topics
- Atrial Fibrillation
- Cardiomyopathy, Hypertrophic, Familial
- Carrier Proteins
- Death, Sudden, Cardiac
- Echocardiography, Doppler
- Heart Failure
- Humans
- Magnetic Resonance Imaging
- Mutation
- Myocardium
- Sarcomeres