Highly-multiplex detection of plasma cell-free human papillomavirus-16 DNA in oropharyngeal carcinoma.

doi:10.1016/j.jcv.2025.105760

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Article

Highly-multiplex detection of plasma cell-free human papillomavirus-16 DNA in oropharyngeal carcinoma.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Feb 2025

Clark Payton, Karasik Natalya, Campbell Shauna R, Woody Neil M, Ku Jamie A, Silver Natalie, Bottalico Danielle, Prendes Brandon L, Lamarre Eric D, Scharpf Joseph, Sussman Tamara A, Geiger Jessica L, Wang Hannah, Chan Timothy A, Koyfman Shlomo A, Miller Jacob A

Abstract excerpt

BACKGROUND: Plasma cell-free Human Papillomavirus DNA (cfHPVDNA) is a biomarker for oropharyngeal carcinoma. Existing diagnostics may be limited by inadequate sensitivity or high cost/complexity for longitudinal monitoring. OBJECTIVES: We hypothesized that sensitive and specific plasma cfHPVDNA detection may be achieved via a highly-multiplex qPCR method. STUDY DESIGN: We designed and validated a single-tube...

Topics

Humans
Human papillomavirus 16
DNA, Viral
Oropharyngeal Neoplasms
Papillomavirus Infections
Sensitivity and Specificity
Cell-Free Nucleic Acids
Real-Time Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Genotype

Female

Middle Aged

Aged

Human Papillomavirus Viruses

Source

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Identifiers

PMID: 39793474
DOI: 10.1016/j.jcv.2025.105760
PMCID: PMC13292461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39793474-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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