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Article

Highly-multiplex detection of plasma cell-free human papillomavirus-16 DNA in oropharyngeal carcinoma.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Feb 2025

Clark Payton, Karasik Natalya, Campbell Shauna R, Woody Neil M, Ku Jamie A, Silver Natalie, Bottalico Danielle, Prendes Brandon L, Lamarre Eric D, Scharpf Joseph, Sussman Tamara A, Geiger Jessica L, Wang Hannah, Chan Timothy A, Koyfman Shlomo A, Miller Jacob A

Abstract excerpt

BACKGROUND: Plasma cell-free Human Papillomavirus DNA (cfHPVDNA) is a biomarker for oropharyngeal carcinoma. Existing diagnostics may be limited by inadequate sensitivity or high cost/complexity for longitudinal monitoring. OBJECTIVES: We hypothesized that sensitive and specific plasma cfHPVDNA detection may be achieved via a highly-multiplex qPCR method. STUDY DESIGN: We designed and validated a single-tube...

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Identifiers

PMID: 39793474
DOI: 10.1016/j.jcv.2025.105760
PMCID: PMC13292461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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