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Article

Toxin-resistant isoforms of Na+/K+-ATPase in snakes do not closely track dietary specialization on toads.

Proceedings. Biological sciences - 16 Nov 2016

Mohammadi Shabnam, Gompert Zachariah, Gonzalez Jonathan, Takeuchi Hirohiko, Mori Akira, Savitzky Alan H

Abstract excerpt

Toads are chemically defended by bufadienolides, a class of cardiotonic steroids that exert toxic effects by binding to and disabling the Na+/K+-ATPases of cell membranes. Some predators, including a number of snakes, have evolved resistance to the toxic effects of bufadienolides and prey regularly on toads. Resistance in snakes to the acute effects of these toxins is conferred by at least two amino acid...

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Identifiers

PMID: 27852804
DOI: 10.1098/rspb.2016.2111
PMCID: PMC5124105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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