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Article

Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage?

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale - 11 Feb 2023

Hudson Thomas J, Pusztaszeri Marc Philippe, Hier Michael P, Forest Veronique-Isabelle, Yang Ji-Wei, Payne Richard J

Abstract excerpt

BACKGROUND: Genomic testing has enhanced pre-surgical decision making for cytologically indeterminate thyroid nodules, but there remains uncertainty regarding RAS mutations. The addition of extra genetic alterations to previous driver mutation panels has been shown to improve predictive value. This study aims to evaluate the relationship between the mutant allele frequency (AF) and likelihood of malignancy in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36774522
DOI: 10.1186/s40463-022-00611-8
PMCID: PMC9921308

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