Article
Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits.
International journal of molecular sciences - 21 Jan 2023
Udosen Brenda, Soremekun Opeyemi, Kamiza Abram, Machipisa Tafadzwa, Cheickna Cisse, Omotuyi Olaposi, Soliman Mahmoud, Wélé Mamadou, Nashiru Oyekanmi, Chikowore Tinashe, Fatumo Segun
Abstract excerpt
High blood pressure (HBP) has been implicated as a major risk factor for cardiovascular diseases in several populations, including individuals of African ancestry. Despite the elevated burden of HBP-induced cardiovascular diseases in Africa and other populations of African descent, limited genetic studies have been carried out to explore the genetic mechanism driving this phenomenon. We performed genome-wide...
Topics
- Humans
- Blood Pressure
- Genome-Wide Association Study
- Cardiovascular Diseases
- Bayes Theorem
- Black People
- Hypertension
- Polymorphism, Single Nucleotide
- Genetic Predisposition to Disease