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Article

Genetic findings in a patient with paradoxical pyoderma gangrenosum induced by brodalumab

8 Dec 2022

Abstract excerpt

We describe a patient with psoriasis who developed pyoderma gangrenosum while on treatment with brodalumab, an anti-interleukin (IL)-17 receptor monoclonal antibody. Genetic analyses revealed heterozygous polymorphisms within the promoter region of the IL-6 (promoter polymorphism –174 G/C) and IL-10 genes (promoter polymorphism –1082 A/G).

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PMID: 36763724
DOI: 10.1093/ced/llac117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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