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Article

Clinical response of CARD14-associated papulosquamous eruption to an anti-interleukin-17A antibody.

The British journal of dermatology - 1 Sept 2022

Klein Benjamin, Treudler Regina, Dumann Konstantin, Boldt Andreas, Schumann Isabell, Simon Jan C, Kunz Manfred

Abstract excerpt

Here we present another family with CARD14-associated papulosquamous eruption, which is characterized by mutations in CARD14 and skin lesions resembling psoriasis and pityriasis rubra pilaris. We show beneficial therapeutic response to anti-IL17A treatment in one patient and performed immunomonitoring of our patient, exhibiting enhanced pSTAT3 levels in T cells before treatment, which normalized after treatment....

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PMID: 35262907
DOI: 10.1111/bjd.21229

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