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Plasmodium sporozoites require the protein B9 to invade hepatocytes

25 Jan 2023

Abstract excerpt

Plasmodium sporozoites are transmitted to a mammalian host during blood feeding by an infected mosquito and invade hepatocytes for initial replication of the parasite into thousands of erythrocyte-invasive merozoites. Here we report that the B9 protein, a member of the 6-cysteine domain protein family, is secreted from sporozoite micronemes and is required for productive invasion of hepatocytes. The N-terminus of...

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PMID: 36761022
DOI: 10.1016/j.isci.2023.106056

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