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Article

Systematic Identification of Plasmodium Falciparum Sporozoite Membrane Protein Interactions Reveals an Essential Role for the p24 Complex in Host Infection.

Molecular & cellular proteomics : MCP - 1 Jan 2021

Knöckel Julia, Dundas Kirsten, Yang Annie S P, Galaway Francis, Metcalf Tom, Gemert Geert-Jan van, Sauerwein Robert W, Rayner Julian C, Billker Oliver, Wright Gavin J

Abstract excerpt

Sporozoites are a motile form of malaria-causing Plasmodium falciparum parasites that migrate from the site of transmission in the dermis through the bloodstream to invade hepatocytes. Sporozoites interact with many cells within the host, but the molecular identity of these interactions and their role in the pathology of malaria is poorly understood. Parasite proteins that are secreted and embedded within...

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Identifiers

PMID: 33515807
DOI: 10.1074/mcp.RA120.002432
PMCID: PMC7950211

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