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Article

Serum folate mediates the associations of MTHFR rs1801133 polymorphism with blood glucose levels and gestational diabetes mellitus in Chinese Han pregnant women.

The British journal of nutrition - 28 Oct 2023

Wang Yunguo, Wang Yiyun, Sun Yao, Zhang Naijian, Liang Xiaoshan, Luo Suhui, Dai Lirong, Sun Chao, Yang Yungui, Li Shuying, Zhang Xumei, Zhang Qiang

Abstract excerpt

This study aimed to explore the mediation effects of one-carbon metabolism (OCM) related nutrients on the association between MTHFR rs1801133 polymorphism and gestational diabetes mellitus (GDM). Folate, vitamin B12 and homocysteine (Hcy) were measured in the serum of 1254 pregnant women. Linear and logistic regressions were used to estimate the associations of OCM nutrients and MTHFR rs1801133 polymorphism with...

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PMID: 36756752
DOI: 10.1017/S0007114523000314

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