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Associations between genetic variants of vitamin D metabolic pathway and gestational diabetes mellitus: the potential mediation role of serum 25(OH)D3.

BMC endocrine disorders - 24 Feb 2026

Hua Linlin, Wang Lina, Cui Lingling, Li Zhiqian, Chen Jiajia, Wang Bing, Zhang Xia, Ma Le

Abstract excerpt

BACKGROUND: Circulating vitamin D concentrations have been recognized as a risk factor for GDM. The pathway genes of vitamin D synthesis and metabolism have been shown to be strongly associated with serum vitamin D. This study aimed to evaluate the association between genetic variations and GDM risk, and to further explore the potential mediating role of serum 25(OH)D3 in these relationships. METHODS: A nested...

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Biomarkers
Calcifediol
Diabetes, Gestational
Follow-Up Studies
Metabolic Networks and Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Calcitriol

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PMID: 41735952
DOI: 10.1186/s12902-026-02199-w
PMCID: PMC13041490

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VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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