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Article

Targeting EGFR Exon 20 Insertions in Non-Small Cell Lung Cancer: Recent Advances and Clinical Updates.

Cancer discovery - 1 Sept 2021

Meador Catherine B, Sequist Lecia V, Piotrowska Zofia

Abstract excerpt

Approximately 10% of EGFR-activating mutations occur as in-frame insertion mutations in exon 20 of the EGFR kinase domain (EGFR ins20). EGFR ins20 mutations have not demonstrated the same sensitivity to early generations of EGFR tyrosine kinase inhibitors (TKI) as canonical activating EGFR mutations such as del19 and L858R. Development of effective therapies for this subset of patients has been challenging, but...

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Identifiers

PMID: 34301786
DOI: 10.1158/2159-8290.CD-21-0226
PMCID: PMC8673432

Genes

EGFR

Variants

Provenance

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