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Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single‐cell RNA sequencing

1 Feb 2023

Abstract excerpt

BACKGROUND: Hirschsprung's disease (HSCR) is a relatively common congenital disability. Accumulating extracellular matrix (ECM) prompts intestinal fibrosis remodelling in the aganglionic segments of HSCR. The contributions of various cellular subsets in the fibrogenesis of HSCR segments are poorly understood. METHODS: Single-cell transcriptomics from 8 aganglionic segments and 5 normal segments of 7 HSCR subjects...

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PMID: 36738110
DOI: 10.1002/ctm2.1193

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