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Article

A novel co-culture assay to evaluate the effects of sympathetic innervation on vascular smooth muscle differentiation.

Bioorganic chemistry - 1 Apr 2023

Jafarkhani Saeed, Khakbiz Mehrdad, Amoabediny Ghasem, Mohammadi Javad, Tahmasebipour Mohammad, Rabbani Hodjattallah, Salimi Ali, Lee Ki-Bum

Abstract excerpt

Dedifferentiation of vascular smooth muscle cells (VSMCs) from a functional phenotype to an inverse synthetic phenotype is a symptom of cardiovascular disorders, such as atherosclerosis and hypertension. The sympathetic nervous system (SNS) is an essential regulator of the differentiation of vascular smooth muscle cells (VSMCs). In addition, numerous studies suggest that SNS also stimulates VSMCs to retain their...

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Identifiers

PMID: 36731293
DOI: 10.1016/j.bioorg.2022.106233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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