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Article

Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves.

EBioMedicine - 1 Aug 2016

Jiao Jiao, Xiong Wei, Wang Lunchang, Yang Jiong, Qiu Ping, Hirai Hiroyuki, Shao Lina, Milewicz Dianna, Chen Y Eugene, Yang Bo

Abstract excerpt

Individuals with bicuspid aortic valves (BAV) are at a higher risk of developing thoracic aortic aneurysms (TAA) than patients with trileaflet aortic valves (TAV). The aneurysms associated with BAV most commonly involve the ascending aorta and spare the descending aorta. Smooth muscle cells (SMCs) in the ascending and descending aorta arise from neural crest (NC) and paraxial mesoderm (PM), respectively. We...

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Source

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Identifiers

PMID: 27394642
DOI: 10.1016/j.ebiom.2016.06.045
PMCID: PMC5006642

Genes

MYH11
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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