Article
TNF-alpha-308A allele, a possible severity risk factor of hemorrhagic manifestation in dengue fever patients.
Tissue antigens - 1 Oct 2004
Fernández-Mestre M T, Gendzekhadze K, Rivas-Vetencourt P, Layrisse Z
Abstract excerpt
Among the several hypothesis postulated to explain the pathogenesis of severe dengue disease, the model of immunopathogenesis is the most supported one with a likely important role played by the cascade of cytokines. This work describes single-nucleotide polymorphism of tumor necrosis factor (TNF)-alpha, interferon-gamma, interleukin (IL)-6, transforming growth factor-beta1, and IL-10 in patients with dengue...
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