Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons.

Abstract excerpt

Despite extensive study, the mechanisms underlying pain after axonal injury remain incompletely understood. Pain after corneal refractive surgery provides a model, in humans, of the effect of injury to trigeminal afferent nerves. Axons of trigeminal ganglion neurons that innervate the cornea are transected by laser-assisted in situ keratomileusis (LASIK). Although most patients do not experience postoperative...

Topics

• Humans
• Male
• Axons
• Cornea
• Eye Pain
• Ganglia, Spinal
• Mutation
• NAV1.7 Voltage-Gated Sodium Channel
• Neurons
• Pain
• Siblings