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YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma

31 Jan 2023

Abstract excerpt

BackgroundMerkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus (MCPyV) large and small T antigens (LT and ST). Despite deep genetic differences between MCPyV-positive and -negative subtypes, current clinical diagnostic markers are indistinguishable, and the expression profile of MCC tumors is, to our knowledge,...

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PMID: 36719743
DOI: 10.1172/jci157171

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