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Article

Evaluation of inherited germline mutations in cancer susceptibility genes among pancreatic cancer patients: a single-center study.

Molecular medicine (Cambridge, Mass.) - 30 Jan 2023

Tavano Francesca, Gioffreda Domenica, Fontana Andrea, Palmieri Orazio, Gentile Annamaria, Latiano Tiziana, Latiano Anna, Latiano Tiziana Pia, Scaramuzzi Matteo, Maiello Evaristo, Bazzocchi Francesca, Perri Francesco

Abstract excerpt

BACKGROUND: Germline mutations in cancer susceptibility genes were identified in pancreatic cancer (PanC) patients with a sporadic disease and in those unselected for family cancer history. METHODS: With the aim to determine the prevalence of germline predisposition genes mutations in PanC, and to evaluate whether they were associated with the presence of PanC, we profiled a custom AmpliSeq panel of 27 cancer...

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PMID: 36717774
DOI: 10.1186/s10020-023-00600-1
PMCID: PMC9885574

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