Selective degradation of the p53‐R175H oncogenic hotspot mutant by an RNA aptamer‐based PROTAC

Abstract excerpt

To the Editor: TP53 encodes the tumour suppressor protein p53, a master regulator of genomic integrity and cell survival, and is the most frequently mutated gene.1 p53 mutant proteins are stabilised and can acquire dominant-negative or oncogenic gain-of-function activities, thereby promoting malignant transformation, metastasis and chemoresistance.2, 3 Proteolysis targeting chimeras (PROTACs) that hijack cellular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromatin Remodeling and Cancer
• Share to Peptidase Inhibition and Analysis
• Share to Protein Degradation and Inhibitors