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Article

Phenotypic correlations of CALR mutation variant allele frequency in patients with myelofibrosis

30 Jan 2023

Abstract excerpt

Somatic mutations in calreticulin ( CALR ), encoding for the reticulum-endoplasmic-associated Ca 2+ -binding chaperone protein calreticulin, located at chromosome 19p13.13, represent the second most frequent driver mutation in myeloproliferative neoplasms (MPN) [ 1 , 2 ]. CALR mutation is harbored by 20–30% of patients with essential thrombocythemia (ET) and 25–35% of prefibrotic primary myelofibrosis (pre-PMF)...

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PMID: 36710362
DOI: 10.1038/s41408-023-00786-x

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Phenotypic correlations of CALR mutation variant allele frequency in patients with myelofibrosisPMID 36710362Read ↗

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