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Article

Cardiac toxicity associated with pharmacokinetic drug-drug interaction between crizotinib and sofosbuvir/velpatasvir: A case report.

British journal of clinical pharmacology - 1 Apr 2023

Monribot Anthia, Huillard Olivier, Khoudour Nihel, Préta Laure-Hélène, Blanchet Benoit, Cabanes Laure, Batista Rui, Pallet Nicolas, Chouchana Laurent, Goldwasser François, Sogni Philippe, Thomas-Schoemann Audrey

Abstract excerpt

This case report describes a pharmacokinetic drug-drug interaction between crizotinib, a tyrosine kinase inhibitor, and sofosbuvir/velpatasvir, a direct-acting antiviral drug, leading to cardiac toxicity. A 75-year-old man, with no cardiovascular history but a diagnosis of metastatic nonsmall cell lung cancer with mesenchymal-epithelial transition exon-14 deletion and hepatitis C virus infection genotype 1A,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36709977
DOI: 10.1111/bcp.15674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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