Article
Drug-drug interactions associated with FLT3 inhibitors for acute myeloblastic leukemia: current landscape.
Expert review of clinical pharmacology - 1 Feb 2023
Solana-Altabella Antonio, Megías-Vericat Juan Eduardo, Ballesta-López Octavio, Martínez-Cuadrón David, Montesinos Pau
Abstract excerpt
INTRODUCTION: FLT3 inhibitors (FLT3i) are drugs in which there is limited experience and not yet enough information on the mechanisms of absorption, transport, and elimination; but especially on the potential drug-drug interactions (DDIs). There are therefore risks in the management of FLT3i DDIs (i.e. sorafenib, ponatinib, crenolanib, midostaurin, quizartinib, and gilteritinib) and ignoring them can compromise...
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