Article
Residual phenotypic susceptibility to doravirine in multidrug-resistant HIV-1 from subjects enrolled in the PRESTIGIO Registry.
International journal of antimicrobial agents - 1 Mar 2023
Saladini Francesco, Giammarino Federica, Maggiolo Franco, Ferrara Micol, Cenderello Giovanni, Celesia Benedetto M, Martellotta Ferdinando, Spagnuolo Vincenzo, Corbelli Giulio M, Gianotti Nicola, Santoro Maria M, Rusconi Stefano, Zazzi Maurizio, Castagna Antonella
Abstract excerpt
OBJECTIVES: Doravirine shows a rather distinct resistance profile within the nonnucleoside reverse transcriptase inhibitor (NNRTI) class. This study aimed to evaluate the phenotypic susceptibility to doravirine, rilpivirine and etravirine in a panel of multidrug-resistant (MDR) HIV-1 isolates collected from people living with HIV (PLWH) enrolled in the PRESTIGIO Registry. METHODS: Recombinant viruses expressing...
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