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Article

Impact of HIV-1 Resistance-Associated Mutations on Susceptibility to Doravirine: Analysis of Real-World Clinical Isolates.

Antimicrobial agents and chemotherapy - 17 Nov 2021

Asante-Appiah Ernest, Lai Johnny, Wan Hong, Yang Dongmei, Martin Elizabeth Anne, Sklar Peter, Hazuda Daria, Petropoulos Christos J, Walworth Charles, Grobler Jay A

Abstract excerpt

Clinical management of human immunodeficiency virus type-1 (HIV-1) infection may be negatively impacted by either acquired or transmitted drug resistance. Here, we aim to extend our understanding of the impact of resistance-associated mutations (RAMs) on the susceptibility of clinical isolates to the nonnucleoside reverse transcriptase inhibitor (NNRTI) doravirine. Clinical isolates from people living with HIV-1...

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Identifiers

PMID: 34570651
DOI: 10.1128/AAC.01216-21
PMCID: PMC8597775

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