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Article

Prognostic value of genomic mutation signature associated with immune microenvironment in southern Chinese patients with esophageal squamous cell carcinoma.

Cancer immunology, immunotherapy : CII - 4 Jun 2024

Zhou Yue, Chu Li, Li Shuyan, Chu Xiao, Ni Jianjiao, Jiang Shanshan, Pang Yechun, Zheng Danru, Lu Yujuan, Lan Fangcen, Cai Xiuyu, Yang Xi, Zhu Zhengfei

Abstract excerpt

The genomic landscape of esophageal squamous cell cancer (ESCC), as well as its impact on the regulation of immune microenvironment, is not well understood. Thus, tumor samples from 92 patients were collected from two centers and subjected to targeted-gene sequencing. We identified frequently mutated genes, including TP53, KMT2C, KMT2D, LRP1B, and FAT1. The most frequent mutation sites were ALOX12B (c.1565C > T),...

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Identifiers

PMID: 38832974
DOI: 10.1007/s00262-024-03725-2
PMCID: PMC11150228

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