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Article

Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review.

Alzheimer's research & therapy - 9 Jan 2018

Ygland Emil, van Westen Danielle, Englund Elisabet, Rademakers Rosa, Wszolek Zbigniew K, Nilsson Karin, Nilsson Christer, Landqvist Waldö Maria, Alafuzoff Irina, Hansson Oskar, Gustafson Lars, Puschmann Andreas

Abstract excerpt

BACKGROUND: The MAPT c.1216C > T (p.Arg406Trp; R406W) mutation is a known cause of frontotemporal dementia with Parkinsonism linked to chromosome 17 tau with Alzheimer's disease-like clinical features. METHODS: We compiled clinical data from a new Swedish kindred with R406W mutation. Seven family members were followed longitudinally for up to 22 years. Radiological examinations were performed in six family...

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Identifiers

PMID: 29370822
DOI: 10.1186/s13195-017-0330-2
PMCID: PMC6389050

Genes

MAPT

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Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review.PMID 29370822Read ↗

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