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Transcriptomic analyses of patient peripheral blood with hemoglobin depletion reveal glioblastoma biomarkers

25 Jan 2023

Abstract excerpt

Peripheral blood is gaining prominence as a noninvasive alternative to tissue biopsy to develop biomarkers for glioblastoma (GBM); however, widely utilized blood-based biomarkers in clinical settings have not yet been identified due to the lack of a robust detection approach. Here, we describe the application of globin reduction in RNA sequencing of whole blood (i.e., WBGR) and perform transcriptomic analysis to...

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PMID: 36697401
DOI: 10.1038/s41525-022-00348-3

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