Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study.

EBioMedicine - 1 Feb 2023

Zhao Jian, Stewart Isobel D, Baird Denis, Mason Dan, Wright John, Zheng Jie, Gaunt Tom R, Evans David M, Freathy Rachel M, Langenberg Claudia, Warrington Nicole M, Lawlor Deborah A, Borges Maria Carolina

Abstract excerpt

BACKGROUND: Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. METHODS: We explored the effect of maternal circulating amino acids on fetal growth, proxied by birthweight, using two-sample Mendelian randomisation (MR) and summary data from a genome-wide association study (GWAS) of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Birth Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Development

Share to Genome-Wide Association Study

Share to Genotype

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 36696816
DOI: 10.1016/j.ebiom.2023.104441
PMCID: PMC9879767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study.PMID 36696816Read ↗

Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring BirthweightSemantic proximity Read ↗

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.Semantic proximity Read ↗

Dissecting the relationship between hypertensive disorders of pregnancy and branched-chain amino acids: An integrated investigation combining Mendelian randomization, transcriptomics, and machine learning.Semantic proximity Read ↗

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study.Semantic proximity Read ↗

Causal Association between Birth Weight and Adult Diseases: Evidence from a Mendelian Randomisation AnalysisSemantic proximity Read ↗

Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation.Semantic proximity Read ↗

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factorsSemantic proximity Read ↗

The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study.Semantic proximity Read ↗

Causal effect of lower birthweight on non-alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites.Semantic proximity Read ↗

Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomizationSemantic proximity Read ↗

Impact of fetal and maternal genetically predicted birth weight on cardiometabolic risk: a Mendelian randomization study of cytokine mediation in Europeans.Semantic proximity Read ↗

Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.