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Article

Causal effect of lower birthweight on non-alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2023

Kong Lijie, Ye Chaojie, Wang Yiying, Zheng Jie, Zhao Zhiyun, Li Mian, Xu Yu, Lu Jieli, Chen Yuhong, Xu Min, Wang Weiqing, Ning Guang, Bi Yufang, Wang Tiange

Abstract excerpt

BACKGROUND & AIMS: The causal association of lower birthweight with non-alcoholic fatty liver disease (NAFLD) and the mediating pathways remain unclear. We aimed to investigate the causal, independent association of lower birthweight with NAFLD and identify potential metabolic mediators and their mediation effects in this association. METHODS: We performed two-step, two-sample Mendelian randomization (MR) using...

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PMID: 36719063
DOI: 10.1111/liv.15532

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