Article
Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs.
PLoS genetics - 1 Jan 2023
Lingaas Frode, Tengvall Katarina, Jansen Johan Høgset, Pelander Lena, Hurst Maria H, Meuwissen Theo, Karlsson Åsa, Meadows Jennifer R S, Sundström Elisabeth, Thoresen Stein Istre, Arnet Ellen Frøysadal, Guttersrud Ole Albert, Kierczak Marcin, Hytönen Marjo K, Lohi Hannes, Hedhammar Åke, Lindblad-Toh Kerstin, Wang Chao
Abstract excerpt
Chronic kidney disease (CKD) affects 10% of the human population, with only a small fraction genetically defined. CKD is also common in dogs and has been diagnosed in nearly all breeds, but its genetic basis remains unclear. Here, we performed a Bayesian mixed model genome-wide association analysis for canine CKD in a boxer population of 117 canine cases and 137 controls, and identified 21 genetic regions...
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